Table 1 Activities of chuangxinmycin derivatives
Compounds | MIC (µg/mL) | |||||
|---|---|---|---|---|---|---|
M. tuberculosis | M. phlei | M. smegmatis | ||||
H37Rv | M9483 | M6600 | M3551 | Â | Â | |
CM | 1 | 2 | 1 | 2 | 1 | 4 |
NCM | 4 | / | / | / | 16 | > 32 |
5-F-CM | 4 | 4 | 4 | 8 | 16 | > 32 |
5-F-NCM | > 32 | / | / | / | > 32 | > 32 |
7-F-NCM | 4 | / | / | / | / | > 32 |
6-Cl-CM | 16 | / | / | / | 32 | > 32 |
6-Cl-NCM | 32 | 64 | 32 | 64 | > 32 | > 32 |
7-Cl-NCM | > 32 | / | / | / | > 32 | > 32 |
INH | 0.0625 | R | R | R | / | / |
RIF | 0.125 | R | R | R | / | / |
LZD | 0.25 | S | S | S | / | / |
STR | / | / | / | / | 8 | 4 |