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Fig. 6 | Microbial Cell Factories

Fig. 6

From: Targeted high-level production of chuangxinmycin and its halogenated derivatives with antitubercular activity

Fig. 6

Structure confirmation of new halogenated derivatives and their molecular docking into the target TrpRS. (A) Key HMBC (blue arrows) and 1H -1H COSY (red thick bonds) correlations of 5-F-CM, 5-F-NCM, 7-F-NCM, 6-Cl-NCM and 7-Cl-NCM. (B) Docking of chuangxinmycin derivatives made in this study into a chuangxinmycin-bound crystal structure of TrpRS from Bacillus stearothermophilus (PDB: 7CKI). Docked molecules (magenta) are compared with active site-bound chuangxinmycin (white) from the crystal structure

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Microbial Cell Factories

ISSN: 1475-2859

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