Fig. 8

Comparison of multi-omics data in cytidine biosynthesis networks. The DEGs and DMs related to nucleotide metabolism, carbon metabolism, nitrogen metabolism and amino acid metabolism in recombinant strains were analyzed (Details in Supplementary file 2). Abbreviations: G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; FBP, fructose-1,6-bisphosphate; DHAP, dihydroxyacetone phosphate; GAP, glyceraldehyde-3-phosphate; 1,3-BPG, glycerate 1,3-diphosphate; 3PG, 3-phosphoglycerate; GA, gluconic acid; PEP, phosphoenolpyruvate; PYR, pyruvic acid; OAA, oxaloacetate; MAL, malic acid; SUCC, succinic acid; α-KG, α-ketoglutaric acid; ICIT, isocitrate; CIT, citrate; 6PGL, 6-phosphogluconolactone; 6PG, 6-phosphogluconic acid; RU5P, ribulose 5-phosphate; R5P, ribose 5-phosphate; PRPP, 5-phosphoribosyl-1α-pyrophosphate; IMP, inosinemonphosphate; AMP, adenosine 5’-monophosphate; GMP, guanosine monophosphate; ALA, allantoic acid; L-Glu, L-glutamate; Gln, glutamine; Cit, citrulline; Arg, arginase; L-Asp, L-asparaginase; L-Hom, L-homoserine; L-His, L-histidine; BCAA, branched-chain amino acid; CP, carbamoyl phosphate; N-CA-Asp, N-carbamoyl aspartate; DHD, dihydroorotate; OMP, orotidine 5′-phosphate; UMP, uridine monophosphate; UDP, uridine diphosphate; UTP, uridine triphosphate; CTP, cytidine triphosphate; CDP, cytidine diphosphate; CMP, cytidine monophosphate