Fig. 1
Pathways involved in dopamine biosynthesis and regulation in E. coli. Also, the strain engineering targets are shown either by a red cross to indicate deletion of tyrR or by underline to indicate overexpression of a gene (tyrA, aroF, aroB, aroL). Dashed lines indicate feedback inhibition. G6P: Glucose-6-phosphate; F6P: Fructose-6-phosphate; G3P: Glycerinaldehyde-3-phosphate; PEP: Phosphoenolpyruvate; TCA: Tricarboxylic acid; Ru5P: Ribulose-5-phosphate; E4P: Erythrose-4-phosphate; DAHP: 3-Desoxyarabinoheptulosanat-7-phosphate; CHA: Chorismate; PPA: Prephenate; HPPH: 4-Hydroxyphenylpyruvate; L-TYR: l-tyrosine; PPY: phenylpyruvate; L-PHE: l-phenylalanine; AroF/AroG/AroH: 3-Deoxy-D-arabinoheptulosonat-7-phosphate-synthase; AroA: 5-Enolpyruvoyl-shikimate-3-phosphate-synthase; AroB: 3-Dehydroquinat-synthase; AroK/ AroL: Shikimate-kinase 1 + 2; l-DOPA: 3;4-Dihydroxy-phenylalanin; DQ: Dopaquinone; TyrR: transcriptional regulator; PheA/ TyrA: Chorismate-mutase; TyrB: Tyrosine aminotransferase; HpaBC: 4-hydroxyphenylacetate 3-monooxygenase; Ddc: l-DOPA decarboxylase. The schematic graph was created using PathVisio3 software [61]