Fig. 6

Effect of phosphate metabolism on natamycin production of S. gilvosporeus ATCC 13,326. (a) Schematic of the construction of strains. (b) Overexpressed phoP or phoR enhances the natamycin production. (c) Silenced phoP and phoR decreases the natamycin production. (d) Silenced phoP or phoR represses the expression of natamycin biosynthetic gene cluster. The error bars represent the standard error of the mean. Asterisk denotes statistically significant differences: *** p < 0.001