Fig. 5

Effect of nitrogen metabolism on natamycin production of S. gilvosporeus ATCC 13,326. (a) Adding exogenously glutamate enhances the natamycin production. (b) Adding exogenously glutamine enhances the natamycin production. (c) Schematic of the construction of strains. (d) Overexpressing nasA, nasB, gdhA, and nirB enhances the natamycin production. The error bars represent the standard error of the mean. Asterisk denotes statistically significant differences: *p < 0.05; **p < 0.01; ***p < 0.001