Low-biomass pyruvate production with engineered Vibrio natriegens is accompanied by parapyruvate formation

Table 2 Selection of glucose-based pyruvate production processes by different microorganisms

Strain	Process	Titer g L^− 1	Yield g_Pyr g_Glc⁻¹	Productivity g L^− 1 h^− 1	Reference
V. natriegens Δvnp12 ΔaceE	Batch	41.0	0.51	4.1	This study
V. natriegens ΔVPN1 ΔVPN2 ΔpflB Δlldh Δdldh Δpps1 Δpps2 P2-aceE^TTG P2-ppc^ATG	Fed-batch	54.2	0.57	3.4	[33]
E. coli K-12 Hfr zbi::Tn10 poxB1 Δ(aceEF) rpsL pps-4 pfl-1 ldhA::Kan	Fed-batch	62.0	0.54	1.8	[27]
E. coli K-12 Hfr zbi::Tn10 poxB1 Δ(aceEF) rpsL pps-4 pfl-1 ldhA::Kan arcA726::FRT atpFH::Cam	Fed-batch	90.0	0.68	2.1	[28]
C. glutamicum ΔaceE Δpqo ΔldhA ΔC–T ilvN ΔalaT ΔavtA	Fed-batch	45.0	0.47	0.4	[19]
Evolved S. cerevisiae MATapdc1(− 6,−2)::loxP pdc5(− 6,−2)::loxP pdc6(− 6,−2)::loxP ura3-52	Fed-batch	135.0	0.54	1.4	[21]
Evolved C. glabrata CCTCC M202019	Batch	94.3	0.64	1.2	[70]
C. glabrata IFO 0005	Batch	57.0	0.57	1.0	[23]

ISSN: 1475-2859