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Fig. 5 | Microbial Cell Factories

Fig. 5

From: Lactobacillus gasseri LGV03-derived indole-3-lactic acid ameliorates immune response by activating aryl hydrocarbon receptor

Fig. 5

Biomarkers of the immune function were significantly increased in larval zebrafish following L. gasseri LGV03 supernatant exposure. (A) L. gasseri LGV03 supernatant and indole-3-lactic acid inhibited vinorelbine-induced macrophage reduction in zebrafish model Tg (mpeg-EGFP) (right). Number of macrophages in zebrafish after treatment of vinorelbine and L. gasseri LGV03 supernatant or indole-3-lactic acid (left). (B) L. gasseri LGV03 supernatant and indole-3-lactic acid inhibited vinorelbine-induced neutrophil reduction in zebrafish model Tg (mpx-EGFP) (right). Number of neutrophils in zebrafish after treatment of vinorelbine and L. gasseri LGV03 supernatant or indole-3-lactic acid (left). (C) L. gasseri LGV03 supernatant and indole-3-lactic acid inhibited suppressed vinorelbine-induced T cell decrease in zebrafish model Tg(rag2-DsRed) (right). The dotted box indicates the thymus where T cells gather. Fluorescence intensity of T cells in zebrafish after treatment of vinorelbine and L. gasseri LGV03 supernatant or indole-3-lactic acid (left)

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Microbial Cell Factories

ISSN: 1475-2859

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