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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Salmonella Typhimurium derived OMV nanoparticle displaying mixed heterologous O-antigens confers immunogenicity and protection against STEC infections in mice

Fig. 1

The schematic diagram of S. Typhimurium derived OMV displaying mixed heterologous O-antigens induce an immune response in mice. Two recombinant plasmids synthesizing different E. coli O-antigens were introduced into engineered Salmonella to isolate OMV. The mice were immunized with OMV displaying mixed E. coli O-antigen by intraperitoneal injection. The O-antigen-specific IgG antibodies induced by our OMV possess significant biological functionality to provide protection against the infection of wild-type E. coli

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Microbial Cell Factories

ISSN: 1475-2859

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