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Fig. 7 | Microbial Cell Factories

Fig. 7

From: Metformin regulates cellulase production in Trichoderma reesei via calcium signaling and mitochondrial function

Fig. 7

Impact of metformin on cellulase production in relation to mitochondrial health. (a) Mitochondrial activity in T. reesei QM6a with or without metformin treatment at a concentration of 100 nM was assessed using MitoTracker® Red CMXRos. (b) Higher levels of red fluorescence intensity are associated with improved mitochondrial health, followed by (c) measurement of mitochondrial membrane potential (ΔΨm) with JC-1 dyes. Fluorescence intensity was monitored using automatic inverted fluorescence microscopy. (d) Ratio of red to green fluorescence intensity is indicative of mitochondrial function integrity (**p < 0.01)

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Microbial Cell Factories

ISSN: 1475-2859

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