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Fig. 1 | Microbial Cell Factories

Fig. 1

From: Engineering of Saccharomyces cerevisiae as a platform strain for microbial production of sphingosine-1-phosphate

Fig. 1

Metabolic engineering strategies to produce S1P in S. cerevisiae. Sphingolipids biosynthetic pathways for the production of S1P in S. cerevisiae. To generate a S1P-producing strain, human DES1, ACER1, and SPHK1 genes, encoding sphingolipid delta 4 desaturase, alkaline ceramidase, and sphingosine kinase, respectively, were introduced into the S. cerevisiae. LCB1 and LCB2, subunits of serine palmitoyltransferase; ORM1 and ORM2, Regulator of serine palmitoyltransferase; TSC3, Activator of serine palmitoyltransferase; TSC10, 3-ketosphinganine reductase; LAC1, LAG1, and LIP1, Subunits of ceramide synthase; LCB4 and LCB5, Sphingoid long-chain base kinase; SUR2, Sphinganine C4-hydroxylase; DPL1, Dihydrosphingosine phosphate lyase

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Microbial Cell Factories

ISSN: 1475-2859

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