Skip to main content

Table 2 Effects of the combined use of enzyme and antimicrobial drugs over the isolates

From: The activity of hydrolytic enzymes and antibiotics against biofilms of bacteria isolated from industrial-scale cooling towers

Enzyme, antimicrobial drugs and isolate

MBEC

FIC

Result

 

Not combined

Combined

 

AMG + Cef (E. hormaechei 125)

200 U/mL for enzymes and

< 2 mg/mL for antimicrobial drugs

6,25 U/mL and 2 mg/mL

1,03

Indifferent

AMG + Cef (P. stutzeri 110)

0,0156 U/mL and 1 mg/mL

1,01

Indifferent

AMG + Chlor (A. junii 20)

6,25 U/mL and 2 mg/mL

1,03

Indifferent

AMG + Gen (E. meningoseptica 8)

6,25 U/mL and 0,25 mg/mL

0.15

Synergism

AMG + Mer (K. cryocrescens 40)

3,25 U/mL and 1 mg/mL

0.51

Additive

BAN + Cef (S. maltophilia 94)

1,562 U/mL and 0,5 mg/mL

0.25

Synergism

BAN + Cip (E. mexicanum 63)

0,78 U/mL and 0,125 mg/mL

0.06

Synergism

BAN + Mer (E. hormaechei 152)

0,78 U/mL and 0,0625 mg/mL

0.03

Synergism

Cellulase + Chlor (L. sphaericus 116)

0,78 U/mL and 0,125 mg/mL

0.06

Synergism

Cellulase + Ery (Bacillus sp. Cereus group 1 157)

0,78 U/mL and 0,25 mg/mL

0.12

Synergism

  1. MBEC: Minimal biofilm eradication concentration. FIC: Fractionated inhibitory concentration. Gen: gentamicin; Ery: erythromycin; Cip: ciprofloxacin; Chlor: chloramphenicol; Cef: ceftriaxone. Mer: Meropenem; Cef: Ceftriaxone