Table 3 The MIC values of carbapenems alone and in combination with different inhibitors against engineered strains of E. coli producing KPC-2 cloned β-lactamase
From: Characterization of GQA as a novel β-lactamase inhibitor of CTX-M-15 and KPC-2 enzymes
Isogenic Strains | Type of β-lactamasea | MIC (µg/mL)b | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ertapenem | Meropenem | Imipenem | |||||||||||
Alone | with inhibitors | Alone | with inhibitors | Alone | with inhibitors | ||||||||
GQA | Clav | Taz | GQA | Clav | Taz | GQA | Clav | Taz | |||||
BL10 (pUCP24 vector pET101/D-TOPO®) | – | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 |
TOP10-K6 | KPC-2 | 128 | 0.25 (0.25) | 0.5 (0.25) | 0.25 (0.25) | 128 | 2 (0.25) | 4 (0.50) | 1 (0.50) | 64 | 1 (0.13) | 2 (0.50) | 1 (0.50) |