Table 2 The summary of improved biotin production by metabolic engineering

E. coli

Overexpression of bioB-Bs

16^S

[119]

E. coli

Overexpression of bioXWF-Bs and bioDAYB-Bs

27.0^B; 45^FB

[120]

E. coli

Overexpression of bioBFCDA

1.4^S; 35^FB

[121]

E. coli

Site mutation of iscR

2.0^S

[122]

E. coli

Overexpression of bioABFHCD-Pp and bioW-sam2

12.8^S; 208.7^S

[123]

B. subtilis

Overexpression of bioB-Bs

15^S

[119]

B. subtilis

Overexpression of bioWAFDBI-Bs2

1.1^S; 8^B; 16^MP

[125]

B. subtilis

Using groE promotor to replace the origin one

5.0^S

[126]

B. subtilis

Overexpression of bioWAFDBI-ytbQ-Bs2

5.0^S

[63]

P. mutabilis

Knockout of yigM; repression of birA; Overexpression of bioWIAFD-Bs2

0.18^S

[127]

P. mutabilis

RBS optilization of bioA and bioBFHCD; ΔyigM; birA::EcbirA; overexpression of metK, mtn and bioWIAFD-Bs2

4.6^S;271.9^S

[128]

Agrobacterium/Rhizobium

Overexpression of bioBFCDA

110^FB

[121]

Sphingomonas sp.

Overexpression of bioBFCDA

66^FB

[129]

C. utilis

Overexpression of bio2

1.9^S

[130]