Advances and prospects in microbial production of biotin

Table 1 The summary of improved biotin production by chemical mutagenesis

Host	Biotin analogs	Mutagenic agent	Genotype	Titer (mg/L)	Reference
B. sphaericus	ACM, TVA	NTG	-	9.5^S	[103]
S. marcescens	ACM, TVA	NTG	-	20^S	[104]
S. marcescens	-	-	bioABFCD	200^S	[105]
S. marcescens	Ethionine; S-2-aminoethy-lcysteine	NTG	-	33^S	[106]
			bioABFCD	250^S
			bioABFCD	500^FB
S. marcescens	-	-	bioABFCD	600^FB	[111]
S. marcescens	Ethionine; S-2-aminoethy-lcysteine	NTG	bioBFCD (Chromosome)	120^S	[107]
Kurthia sp.	Acidomycin; TVA; α-methyl dethiobiotin; 2-methyl acidomycin; amiclenomycin; bisnorbiotinol	NTG	-	126^S	[108]
E. coli	ACM, TVA	NTG	-	4.5^S	[109]
E. coli	Threonine analogue	NTG	bioABFCD	970^FB	[110, 111]
P. mutagenesis	Biotin methyl ester; biotin pnitrophenyl; 4-amido-benzo-ic acid; diamino biotin	NTG	bioABFHCD	15 000^B	[114]

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