Shared and more specific genetic determinants and pathways underlying yeast tolerance to acetic, butyric, and octanoic acids

Mota, Marta N.; Matos, Madalena; Bahri, Nada; Sá-Correia, Isabel

doi:10.1186/s12934-024-02309-0

Table 2 Genes involved in vacuolar acidification

From: Shared and more specific genetic determinants and pathways underlying yeast tolerance to acetic, butyric, and octanoic acids

Gene/ORF	Description of the encoded protein function	Susceptibility
Gene/ORF	Description of the encoded protein function	C2	C4	C8
DBF2	Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis	+	+	+
MEH1	Subunit of EGO/GSE complex; vacuolar/endosomal membrane-associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest	0	0	+
PFK2	Beta subunit of heterooctameric phosphofructokinase, involved in glycolysis	+ +	+ +	+ +
RAV2	Subunit of RAVE complex	0	+	+
RRG1	No demonstrated function but Rrg1p may be required for vacuolar acidification, efficient 5′ processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance	0	+	+
VMA1	Subunit A of the V1 peripheral membrane domain of V-ATPase	+	+	+
VMA10	Subunit G of the V1 peripheral membrane domain of V-ATPase. Vma10p is involved in vacuolar acidification	+ +	+	+
VMA11	Vacuolar ATPase V0 domain subunit c′. Vma11p is involved in proton transport activity	+	+	+
VMA13	Subunit H of the V1 peripheral membrane domain of V-ATPase. Vma13p serves as an activator or a structural stabilizer of the V-ATPase	0	0	+
VMA16	Subunit c′′ of the vacuolar ATPase	+	+	+
VMA2	Subunit B of V1 peripheral membrane domain of vacuolar H⁺-ATPase	+	+	+
VMA3	Proteolipid subunit c of the V0 domain of vacuolar H⁺ -ATPase. Vma3p is required for vacuolar acidification	+	+	+
VMA5	Subunit C of the V1 peripheral membrane domain of V-ATPase. Vma5p is required for the V1 domain to assemble onto the vacuolar membrane	+	+	+
VMA7	Subunit F of the V1 peripheral membrane domain of V-ATPase. Vma7p is required for the V1 domain to assemble onto the vacuolar membrane;	+	+	+
VPH1	Subunit a of the vacuolar-ATPase V0 domain located in vacuolar V-ATPase complexes	+	+	+
VPH2	Integral membrane protein required for V-ATPase function. Vph2p is involved in the assembly of the V-ATPase	+	+	+
VPS3	Component of CORVET membrane tethering complex. Vps3p is involvedin the acidification of the vacuolar lumen and in the assembly of the vacuolar H⁺-ATPase	+	+	+

The table includes the list of genes, involved in vacuolar acidification, identified in this study as determinants of yeast tolerance to acetic acid (C2), butyric acid (C4), or octanoic acid (C8). Table elaborated as described in Table 1

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ISSN: 1475-2859

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