Fig. 8

HI and VN antibody titers in mice after immunization with the engineered L. plantarum strains. Bronchoalveolar lavage fluid (BALF), intestinal lavage fluid (ILF) and sera were collected for 1 week after the third immunization for HI, VN antibody titers detection. a–f HI antibody titers was determined with swIAV H1N1 virus, the results were calculate by value of log2. h–m The VN antibody titers were determined against 100 TCID50 swIAV H1N1 virus, the results were calculated by value of log10 finally. Significant differences of vaccination with univalent inactivated vaccine group were recorded (*p < 0.05, **P < 0.01, ***P < 0.001)