Skip to main content
Fig. 3 | Microbial Cell Factories

Fig. 3

From: Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative

Fig. 3

Proposed biosynthesis pathway of PM100117 and PM100118 polyketide skeleton. LD loading domain, M1–M20 extension modules. Polyketide synthase domains are as follows: KS ketosynthase, AT acyltransferase, KR ketoreductase, DH dehydratase, ER enoylreductase, ACP acyl-carrier-protein. Grey circles indicate inconsistencies between catalytic domains of the PKS modules and chemical functional groups in the polyketide. Numbers indicate aglycone carbon positions and asterisks mark the carbon where presence of a methyl group was expected

Back to article page

Microbial Cell Factories

ISSN: 1475-2859

Contact us