Fig. 2

Chemical genomic profiling of [EMIM]Cl reveals mitochondrial genes are highly sensitive. Of the top 20 most significantly sensitive deletion mutants grown aerobically in YPD with 10 µg/mL [EMIM]Cl, eight were annotated to the mitochondrion (a). We tested the individual sensitivities of the top two most significantly sensitive and resistant mutants compared to the control strain (b, c) using an eight point dose curve. Mutants of ARG2 and QCR2 had significantly lower growth in 0.5 % [EMIM] Cl compared to the WT, whereas mutants of PTK2 and SKY1 grew significantly better (d). (n = 3, Mean ± S.E)