Figure 1

TDP-43 and HNRPDL domain architecture. Cartoons of proteins TDP-43 and HNRPDL show the domain architecture, where RRM accounts for RNA recognition motif and are represented in blue, and predicted disordered regions and prion domains (PrD) are shown in striped green and red, respectively. The places where RRM domains as assigned according to PFAM overlay with disordered predicted regions were assumed to correspond to canonical RRM domains.